Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation
Metadatos
Afficher la notice complèteEditorial
Frontiers
Materia
Controlled delivery Polymeric PH responsive Tramadol HCL Controlled drug delivery Toxicity studies
Date
2023-05-26Referencia bibliográfica
Abdullah Z, Ashraf MU, Barkat K, Badshah SF, Rehman U, Razzaq A, Mahmood A, Ulhaq F, Chopra H, Rashid S, Valko M, Alomar S, Kuca K and Sharma R (2023), Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation. Front. Bioeng. Biotechnol. 11:1190322. [doi: 10.3389/fbioe.2023.1190322]
Patrocinador
Project (2216/2023-2024), Scholars Visiting Program (University of Granada); Researchers Supporting Project (number RSP 2023R35), King Saud UniversityRésumé
Introduction: The objective of current project was to formulate a system for
controlled delivery of Tramadol HCl (TRD), an opioid analgesic used in the
treatment of moderate to severe pain.
Methods: For this purpose, a pH responsive AvT-co-poly hydrogel network was
formulated through free radical polymerization by incorporating natural polymers
i.e., aloe vera gel and tamarind gum, monomer and crosslinker. Formulated
hydrogels were loaded with Tramadol HCl (TRD) and evaluated for percent
drug loading, sol-gel fraction, dynamic and equilibrium swelling, morphological
characteristics, structural features and in-vitro release of Tramadol HCl.
Results and Discussions: Hydrogels were proved to be pH sensitive as remarkable
dynamic swelling response ranging within 2.94g/g-10.81g/g was noticed at pH 7.4
as compared to pH 1.2. Percent drug loading was in the range of 70.28%-90.64%
for all formulations. Thermal stability and compatibility of hydrogel components
were validated by DSC analysis and FTIR spectroscopy. Controlled release pattern
of Tramadol HCl from the polymeric network was confirmed as maximum release
of 92.22% was observed for over a period of 24 hours at pH 7.4. Moreover, oral
toxicity studies were also conducted in rabbits to investigate the safety of
hydrogels. No evidence of any toxicity, lesions and degeneration was reported,
confirming the biocompatibility and safety of grafted system