Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications
Metadatos
Mostrar el registro completo del ítemEditorial
MDPI
Materia
Diclofenac acid Nanocrystals Clays Dermal delivery
Fecha
2023-04-16Referencia bibliográfica
Ruggeri, M.; Sánchez-Espejo, R.; Casula, L.; Sandri, G.; Perioli, L.; Cardia, M.C.; Lai, F.; Viseras, C. Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications. Pharmaceutics 2023, 15, 1253. [https://doi.org/10.3390/pharmaceutics15041253]
Patrocinador
Junta de Andalucia P18-RT-3786; UniCA-Progetti biennali di Ateneo Finanziati dalla Fondazione di Sardegna 2018 CUP F741I19000950007Resumen
Bentonite or palygorskite-based hydrogels have recently been suggested as a strategy to
increase bioavailability and control the retention and release of therapeutic candidates. In this work,
clay-based hydrogels loaded with diclofenac acid nanocrystals have been successfully designed and
developed. The aim was to improve diclofenac solubility, its dissolution rate and to enhance its local
bioavailability after topical application. For this purpose, diclofenac acid nanocrystals were prepared
by wet media milling technology and then loaded into inorganic hydrogels based on bentonite
and/or palygorskite. Diclofenac acid nanocrystals were characterized by morphology, size, and
zeta potential. Moreover, rheological behavior, morphology, solid state, release studies, and in vitro
skin penetration/permeation of diclofenac acid nanocrystals-loaded hydrogels were performed.
The hydrogels were characterized by a crystalline structure, and demonstrated that the inclusion
of diclofenac in clay-based hydrogels resulted in an increased thermal stability. The presence of
both palygorskite and bentonite reduced nanocrystal mobility, and consequently its release and
penetration into the skin. On the other hand, bentonite- or palygorskite-based hydrogels revealed
great potential as an alternative strategy to enhance topical bioavailability of DCF nanocrystals,
enhancing their penetration to the deeper skin layers.