Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts
Identificadores
URI: https://hdl.handle.net/10481/81769Metadata
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García Recio, Enrique; Costela Ruiz, Víctor Javier; Melguizo Rodríguez, Lucía Raquel; Ramos Torrecillas, Javier; Illescas Montes, Rebeca; Luna Bertos, María Elvira De; Ruiz Rodríguez, ConcepciónEditorial
Springer Nature
Materia
Bisphenol-F Bisphenol-S Bisphenol AF Osteoblast Cellular viability Cellular differentiation
Date
2023-05-17Referencia bibliográfica
García-Recio, E., Costela-Ruiz, V.J., Melguizo-Rodríguez, L. et al. Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts. Arch Toxicol (2023).
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Funding for open access publishing: Universidad de Granada/ CBUAAbstract
Bisphenol A (BPA) analogs, like BPA, could have adverse effects on human health including bone health. The aim was to
determine the effect of BPF, BPS and BPAF on the growth and differentiation of cultured human osteoblasts. Osteoblasts
primary culture from bone chips harvested during routine dental work and treated with BPF, BPS, or BPAF for 24 h at doses
of 10 –5 , 10 –6 , and 10 –7 M. Next, cell proliferation was studied, apoptosis induction, and alkaline phosphatase (ALP) activity.
In addition, mineralization was evaluated at 7, 14, and 21 days of cell culture in an osteogenic medium supplemented with BP
analog at the studied doses. BPS treatment inhibited proliferation in a dose-dependent manner at all three doses by inducing
apoptosis; BPF exerted a significant inhibitory effect on cell proliferation at the highest dose alone by an increase of apopto-
sis; while BPAF had no effect on proliferation or cell viability. Cell differentiation was adversely affected by treatment with
BPA analogs in a dose-dependent, observing a reduction in calcium nodule formation at 21 days. According to the results
obtained, these BPA analogs could potentially pose a threat to bone health, depending on their concentration in the organism.
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