Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases
Metadatos
Afficher la notice complèteEditorial
Frontiers Media
Materia
Cardiovascular diseases Coronary artery disease Stents Atherosclerosis Cancer Nanotechnology Vascular tissue engineering
Date
2023-03-16Referencia bibliográfica
Barungi S, Hernández-Camarero P, Moreno-Terribas G, Villalba-Montoro R, Marchal JA, López-Ruiz E and Perán M (2023), Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases. Front. Cell Dev. Biol. 11:1148768. doi: 10.3389/fcell.2023.1148768
Patrocinador
FPU grant from the Ministry of Education, Culture and Sport; University of Jaen, Accion I apoyo a la investigacion BIO-349; Modeling Nature (MNat) QUAL21-11Résumé
Cardiovascular diseases (CVD) are the leading causes of death and disability in the
world. Among all CVD, the most common is coronary artery disease (CAD). CAD
results from the complications promoted by atherosclerosis, which is
characterized by the accumulation of atherosclerotic plaques that limit and
block the blood flow of the arteries involved in heart oxygenation.
Atherosclerotic disease is usually treated by stents implantation and
angioplasty, but these surgical interventions also favour thrombosis and
restenosis which often lead to device failure. Hence, efficient and long-lasting
therapeutic options that are easily accessible to patients are in high demand.
Advanced technologies including nanotechnology or vascular tissue engineering
may provide promising solutions for CVD. Moreover, advances in the
understanding of the biological processes underlying atherosclerosis can lead
to a significant improvement in the management of CVD and even to the
development of novel efficient drugs. To note, over the last years, the
observation that inflammation leads to atherosclerosis has gained interest
providing a link between atheroma formation and oncogenesis. Here, we have
focused on the description of the available therapy for atherosclerosis, including
surgical treatment and experimental treatment, the mechanisms of atheroma
formation, and possible novel therapeutic candidates such as the use of anti-
inflammatory treatments to reduce CVD.