Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review
Metadatos
Afficher la notice complèteAuteur
Pineda Lancheros, Laura Elena; Gálvez Navas, José María; Membrive Jiménez, María José; Sánchez Martín, Almudena; Ramírez Tortosa, María Carmen; Ramírez Tortosa, CristinaEditorial
MDPI
Materia
Non-small-cell lung cancer Vitamin D Overall survival Progression-free survival Singlenucleotide polymorphisms VDR CYP27B1 CYP2R1 GC CYP24A1
Date
2023-03-21Referencia bibliográfica
Pineda-Lancheros, L.E.; Gálvez-Navas, J.M.; Rojo-Tolosa, S.; Membrive-Jiménez, C.; Valverde-Merino,M.I.; Martínez-Martínez, F.; Sánchez-Martín, A.; Ramírez-Tortosa,M.; Pérez-Ramírez, C.; Jiménez-Morales, A. Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review. Nutrients 2023, 15, 1525. [https://doi.org/10.3390/nu15061525]
Patrocinador
The Virgen de las Nieves University Hospital Biobank was supported by grants co-funded by ERDF funds (EU) from the Instituto de Salud Carlos III (PT13/0010/0039).Résumé
The objective of this systematic review was to provide a compilation of all the literature
available on the association between single-nucleotide polymorphisms (SNPs) in the genes involved
in the metabolic pathway of vitamin D and overall survival (OS) and progression-free survival
(PFS) in patients with non-small cell lung cancer (NSCLC). This systematic review was conducted in
accordance with the PRISMA guidelines. It included all the literature published up to 1 November
2022 and was carried out in four databases (Medline [PubMed], Scopus,Web of Science, and Embase),
using the PICO strategy, with relevant keywords related to the objective. The quality of the studies
included was evaluated with an assessment tool derived from the Strengthening the Reporting
of Genetic Association Studies (STREGA) statement. Six studies were included in this systematic
review. Our findings showed that the BsmI (rs1544410), Cdx-2 (rs11568820), FokI (rs2228570), ApaI
(rs7975232), TaqI (rs731236), rs4646536, rs6068816, rs7041, and rs10741657 SNPs in the genes that play
a part in vitamin D synthesis (CYP2R1, CYP27B1), transport (GC), and metabolism (CYP24A1), as
well as in the vitamin D receptor (VDR), are associated with OS and/or PFS in patients with NSCLC.
The SNPs in VDR have been the most extensively analyzed. This systematic review summed up the
available evidence concerning the association between 13 SNPs in the main genes involved in the
vitamin D metabolic pathway and prognosis in NSCLC. It revealed that SNPs in the VDR, CYP27B1,
CYP24A1, GC, and CYP2R1 genes could have an impact on survival in this disease. These findings
suggest the identification of prognostic biomarkers in NSCLC patients. However, evidence remains
sparse for each of the polymorphisms examined, so these findings should be treated with caution.