Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember?
Metadatos
Mostrar el registro completo del ítemEditorial
Frontiers
Materia
Adult neurogenesis Hippocampus Nutrients Perinatal programming Gut microbiota
Fecha
2023-02-23Referencia bibliográfica
Melgar-Locatelli S, de Ceglia M, Mañas-Padilla MC, Rodriguez-Pérez C, Castilla-Ortega E, Castro-Zavala A and Rivera P (2023) Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember? Front. Neurosci. 17:1147269. [doi: 10.3389/fnins.2023.1147269]
Patrocinador
Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas grant number 2020/048; Consejería de Universidad, Investigación e Innovación grant number PROYEXCEL_0029. P.R. (CP19/00068) holds a “Miguel Servet I” research contract from the National System of Health, ERDF-EU-ISCIII. MC holds a postdoctoral research contract from Consejeria de Salud – Junta de Andalucia (RH 0081-2021).; Grant PID2020-114374RB-I00 funded by MCIN/AEI/10.13039/501100011033 (CR-P and EC-O); Junta de Andalucía-Consejería de Universidad, Investigación e Innovación - Proyecto P21_00777 (CR-P and EC-O)Resumen
Neurogenesis is a complex process by which neural progenitor cells
(NPCs)/neural stem cells (NSCs) proliferate and differentiate into new neurons
and other brain cells. In adulthood, the hippocampus is one of the areas with
more neurogenesis activity, which is involved in the modulation of both emotional
and cognitive hippocampal functions. This complex process is affected by many
intrinsic and extrinsic factors, including nutrition. In this regard, preclinical studies
performed in rats and mice demonstrate that high fats and/or sugars diets have
a negative effect on adult hippocampal neurogenesis (AHN). In contrast, diets
enriched with bioactive compounds, such as polyunsaturated fatty acids and
polyphenols, as well as intermittent fasting or caloric restriction, can induce
AHN. Interestingly, there is also growing evidence demonstrating that offspring
AHN can be affected by maternal nutrition in the perinatal period. Therefore,
nutritional interventions from early stages and throughout life are a promising
perspective to alleviate neurodegenerative diseases by stimulating neurogenesis.
The underlying mechanisms by which nutrients and dietary factors affect AHN
are still being studied. Interestingly, recent evidence suggests that additional
peripheral mediators may be involved. In this sense, the microbiota-gut-brain axis
mediates bidirectional communication between the gut and the brain and could
act as a link between nutritional factors and AHN. The aim of this mini-review
is to summarize, the most recent findings related to the influence of nutrition
and diet in the modulation of AHN. The importance of maternal nutrition in
the AHN of the offspring and the role of the microbiota-gut-brain axis in the
nutrition-neurogenesis relationship have also been included.