Involvement of redox signalling in tumour cell dormancy and metastasis
Metadata
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Puente Cobacho, Beatriz; Varela López, Alfonso; Quiles Morales, José Luis; Vera Ramírez, LauraEditorial
Springer
Materia
Oxidative stress Redox signalling Tumour cell dormancy Metastasis
Date
2023-01-26Referencia bibliográfica
Puente-Cobacho, B... [et al.]. Involvement of redox signalling in tumour cell dormancy and metastasis. Cancer Metastasis Rev (2023). [https://doi.org/10.1007/s10555-022-10077-9]
Sponsorship
Universidad de Granada/CBUA; Junta de Andalucia PI-0068-2021 PI-0072-2019; Consejeria de Universidad, Investigacion e Innovacion de la Junta de Andalucia (Spain) EMERGIA20_00313Abstract
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the
complexity of tumour cellular and molecular biology. This knowledge has been successfully implemented in the clinical
practice to treat primary tumours. In contrast, much less progress has been made in the development of new therapies against
metastasis, which are the main cause of cancer-related deaths. More recently, the role of epigenetic and microenviromental
factors has been shown to play a key role in tumour progression. Free radicals are known to communicate the intracellular
and extracellular compartments, acting as second messengers and exerting a decisive modulatory effect on tumour cell
signalling. Depending on the cellular and molecular context, as well as the intracellular concentration of free radicals and
the activation status of the antioxidant system of the cell, the signalling equilibrium can be tilted either towards tumour cell
survival and progression or cell death. In this regard, recent advances in tumour cell biology and metastasis indicate that
redox signalling is at the base of many cell-intrinsic and microenvironmental mechanisms that control disseminated tumour
cell fate and metastasis. In this manuscript, we will review the current knowledge about redox signalling along the different
phases of the metastatic cascade, including tumour cell dormancy, making emphasis on metabolism and the establishment
of supportive microenvironmental connections, from a redox perspective.