Influence of Nutritional Parameters on the Evolution, Severity and Prognosis of Critically Ill Patients with COVID-19
Metadatos
Afficher la notice complèteAuteur
Gamarra Morales, Yenifer; Machado Casas, Juan Francisco; Herrera Quintana, Lourdes María; Vázquez Lorente, Héctor; Castaño Pérez, José; Pérez Villares, José Miguel; Planells Del Pozo, Elena MaríaEditorial
MDPI
Materia
COVID-19 Nutritional status Nutritional biomarkers Morbidity Mortality
Date
2022-12-16Referencia bibliográfica
Gamarra-Morales, Y... [et al.]. Influence of Nutritional Parameters on the Evolution, Severity and Prognosis of Critically Ill Patients with COVID-19. Nutrients 2022, 14, 5363. [https://doi.org/10.3390/nu14245363]
Patrocinador
Spanish Carlos III Health Institute; European Regional Development Fund (ERDF) Andalucia FIS PI10/1993; Spanish Government REF. A-CTS-708-UGR20 REF. FPU18/03702 REF. FPU18/03655Résumé
This study evaluated the clinical and nutritional status, the evolution over three days, and
the relationship between nutritional, inflammatory, and clinical parameters of critically ill patients
with COVID-19. A longitudinal study was conducted in the Intensive Care Unit of the Virgen
de las Nieves University Hospital in Granada (Spain). The study population comprised patients
with a positive polymerase chain reaction test for COVID-19 presenting critical clinical involvement.
Clinical outcomes were collected, and inflammatory and nutritional parameters (albumin, prealbumin,
transferrin, transferrin saturation index, cholesterol, triglycerides and Controlling Nutritional Status
(CONUT) score) were determined. A total of 202 critical patients with COVID-19 were selected,
presenting highly altered clinical-nutritional parameters. The evolution experienced by the patients
on the third day of admission was a decrease in albumin (p < 0.001) and an increase in prealbumin
(p < 0.001), transferrin (p < 0.002), transferrin saturation index (p < 0.018), and cholesterol (p < 0.001).
Low levels of albumin, prealbumin (on the third day) and high CONUT score (on the third day)
showed an association with higher mortality. Nutritional variables were inversely correlated with
clinical and inflammatory parameters. Critically ill patients with COVID-19 have poor nutritional
status related to a poor prognosis of disease severity and mortality.