Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial
Metadata
Show full item recordEditorial
Frontiers
Materia
Stroke Mindfulness Physical exercise Computerized cognitive training Neuroimaging Biomarkers
Date
2022-09-29Referencia bibliográfica
Bermudo-Gallaguet A... [et al.] (2022) Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial. Front. Aging Neurosci. 14:936077. doi: [10.3389/fnagi.2022.936077]
Sponsorship
Fundacio LaMarato de TV3 201717.30.31.32; ICREA; Maria de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona) MDM-2017-0729; Ministry of Science and Innovation, Spain (MICINN) Spanish Government; AB-G pre-doctoral fellowship FPU18/04344Abstract
Background: Post-stroke cognitive and emotional complications are frequent
in the chronic stages of stroke and have important implications for the
functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or
computerized cognitive training (CCT) may benefit stroke patients by
impacting neuroplasticity and brain health.
Materials and methods: One hundred and forty-one chronic stroke patients
are randomly allocated to receive mindfulness-based stress reduction + CCT
(n = 47), multicomponent PE program + CCT (n = 47), or CCT alone
(n = 47). Interventions consist of 12-week home-based programs five days
per week. Before and after the interventions, we collect data from cognitive,
psychological, and physical tests, blood and stool samples, and structural and
functional brain scans.
Results: The effects of the interventions on cognitive and emotional
outcomes will be described in intention-to-treat and per-protocol analyses.
We will also explore potential mediators and moderators, such as
genetic, molecular, brain, demographic, and clinical factors in our perprotocol
sample.
Discussion: The MindFit Project is a randomized clinical trial that aims
to assess the impact of mindfulness and PE combined with CCT on
chronic stroke patients’ cognitive and emotional wellbeing. Furthermore,
our design takes a multimodal biopsychosocial approach that will generate
new knowledge at multiple levels of evidence, from molecular bases to
behavioral changes.