The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice
Metadatos
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Ruiz Malagón, Antonio Jesús; Rodríguez Sojo, María Jesús; Hidalgo García, Laura; Molina Tijeras, José Alberto; García García, Federico; Romero Pérez, Miguel; Duarte Pérez, Juan Manuel; Díez Echave, Patricia; Rodríguez Cabezas, María Elena; Rodríguez Nogales, Alba; Gálvez Peralta, Julio JuanEditorial
MDPI
Materia
Thymus serpyllum High fat diet Obesity Antioxidant Anti-inflammatory Gut microbiota
Fecha
2022-05-28Referencia bibliográfica
Ruiz-Malagón, A.J... [et al.]. The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice. Antioxidants 2022, 11, 1073. [https://doi.org/10.3390/antiox11061073]
Patrocinador
Junta de Andalucia CTS 164; Instituto de Salud Carlos III European Commission PI19.01058; Spanish Government AGL201567995-C3-3-R; European Commission; Instituto de Salud Carlos IIIResumen
Nowadays, there is an increasing interest in alternative therapies in the treatment of
metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate
the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-
induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status
and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice.
The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract
ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being
involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity
and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut
microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty
acid producing bacteria, which have been associated with the maintenance of gut permeability and
weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a
positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These
effects may be mediated by modulation of the gut microbiota.