Caffeine and Chlorogenic Acid Combination Attenuate Early-Stage Chemically Induced Colon Carcinogenesis in Mice: Involvement of oncomiR miR-21a-5p
Metadatos
Afficher la notice complèteAuteur
Rocha Bartolomeu, Ariane; Griñán Lisón, Carmen; Marchal Corrales, Juan Antonio; García Chaves, María ÁngelEditorial
MDPI
Materia
Caffeine Chlorogenic acid Chemically induced colon carcinogenesis miRNA expression Mice
Date
2022-06-04Referencia bibliográfica
Bartolomeu, A.R... [et al.]. Caffeine and Chlorogenic Acid Combination Attenuate Early-Stage Chemically Induced Colon Carcinogenesis in Mice: Involvement of oncomiR miR-21a-5p. Int. J. Mol. Sci. 2022, 23, 6292. [https://doi.org/10.3390/ijms23116292]
Patrocinador
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) 001; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2017/26217-7 2016/12015-0 2016/14420-0; Junta de Andalucia RH-0139-2020Résumé
Colorectal cancer (CRC) is one of most common cancers worldwide, with high rates
of mortality. Epidemiological findings demonstrate that coffee consumption reduces the risk of
developing CRC by ~13%. In general, in vivo and in vitro findings demonstrate the antiproliferative,
antioxidant and proapoptotic effects of brewed coffee or major bioavailable coffee compounds.
Thus, it was assessed whether caffeine (CAF) and/or chlorogenic acid (CGA) attenuates the earlystage
of chemically induced mouse colon carcinogenesis. Male Swiss mice were submitted to a
1,2-dimethylhydrazine/deoxycholic acid (DMH/DCA)-induced colon carcinogenesis model. These
animals received CAF (50 mg/kg), CGA (25 mg/kg) or CAF+CGA (50 + 25 mg/kg) intragastrically for
five times/week for ten weeks. CAF+CGA had the most pronounced effects on decreasing epithelial
cell proliferation (Ki-67) and increasing apoptosis (cleaved caspase-3) in colonic crypts. This treatment
also decreased the levels of proinflammatory cytokines IL-6, IL-17 and TNF- , and downregulated
the oncomiR miR-21a-5p in the colon. Accordingly, the analysis of miR-21a-5p targets demonstrated
the genes involved in the negative regulation of proliferation and inflammation, and the positive
regulation of apoptosis. Ultimately, CAF+CGA attenuated preneoplastic aberrant crypt foci (ACF)
development. Our findings suggest that a combination of coffee compounds reduces early-stage
colon carcinogenesis by the modulation of miR-21a-5p expression, highlighting the importance of
coffee intake to prevent CRC.