L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis
Metadatos
Afficher la notice complèteEditorial
MDPI
Materia
L-serine BAT Fasting Obesity Body weight Weight regain Energy expenditure
Date
2022-05-04Referencia bibliográfica
López-Gonzales, E... [et al.]. L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis. Nutrients 2022, 14, 1922. [https://doi.org/10.3390/nu14091922]
Patrocinador
Uehara Memorial Foundation 201830047; Alexander von Humboldt FoundationRésumé
Weight regain after fasting, often exceeding the pre-fasting weight, is a common phenomenon
and big problem for the treatment of obesity. Thus, novel interventions maintaining
reduced body weight are critically important to prevent metabolic disease. Here we investigate the
metabolic effects of dietary L-serine supplementation, known to modulate various organ functions.
C57BL/6N-Rj male mice were supplemented with or without 1% L-serine in their drinking water and
fed with a chow or high-fat diet. Mice were fed either ad libitum or subjected to repeated overnight
fasting. Body weight, body composition, glucose tolerance and energy metabolism were assessed.
This was combined with a detailed analysis of the liver and adipose tissues, including the use of
primary brown adipocytes to study mitochondrial respiration and protein expression. We find that
L-serine supplementation has little impact on systemic metabolism in ad libitum-fed mice. Conversely,
L-serine supplementation blunted fasting-induced body weight regain, especially in diet-induced
obese mice. This reduction in body weight regain is likely due to the increased energy expenditure,
based on elevated brown adipose tissue activity. Thus, L-serine supplementation during and after
weight-loss could reduce weight regain and thereby help tackle one of the major problems of current
obesity therapies.