Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds
Metadatos
Afficher la notice complèteAuteur
Fernández Ochoa, Álvaro; Cádiz Gurrea, María de la Luz; Fernández Moreno, Patricia; Rojas García, Alejandro; Arráez Román, David; Segura Carretero, AntonioEditorial
MDPI
Materia
Analytical chemistry Bioactive compounds Bioavailability Metabolism Phytochemicals Phenolic compounds Metabolomics Chromatography Mass spectrometry Untargeted
Date
2022-01-25Referencia bibliográfica
Fernández-Ochoa, Á... [et al.]. Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds. Molecules 2022, 27, 777. [https://doi.org/10.3390/molecules27030777]
Patrocinador
Ministry of Science, Innovation and Universities RTI2018-096724-B-C22; Junta de Andalucia A-AGR-226-UGR20 P18-TP-3589 AGR274 265Résumé
The study of the bioavailability of bioactive compounds is a fundamental step for the
development of applications based on them, such as nutraceuticals, functional foods or cosmeceuticals.
It is well-known that these compounds can undergo metabolic reactions before reaching therapeutic
targets, which may also affect their bioactivity and possible applications. All recent studies that
have focused on bioavailability and metabolism of phenolic and terpenoid compounds have been
developed because of the advances in analytical chemistry and metabolomics approaches. The
purpose of this review is to show the role of analytical chemistry and metabolomics in this field
of knowledge. In this context, the different steps of the analytical chemistry workflow (design
study, sample treatment, analytical techniques and data processing) applied in bioavailability and
metabolism in vivo studies are detailed, as well as the most relevant results obtained from them.