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Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review
dc.contributor.author | Toledano Pérez, Manuel | |
dc.contributor.author | Toledano Osorio, Manuel | |
dc.contributor.author | Carrasco Carmona, Álvaro | |
dc.contributor.author | Toledano Osorio, María | |
dc.contributor.author | Osorio Ruiz, Raquel | |
dc.date.accessioned | 2022-03-09T11:49:49Z | |
dc.date.available | 2022-03-09T11:49:49Z | |
dc.date.issued | 2022-02-08 | |
dc.identifier.citation | Toledano, M... [et al.]. Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review. Polymers 2022, 14, 642. [https://doi.org/10.3390/polym14030642] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/73245 | |
dc.description | This work was supported by the Ministry of Economy and Competitiveness and the European Regional Development Fund (Project PID2020-114694RB-100 MINECO/AEI/FEDER/UE). M.T.-O. holds a FPU fellowship from the Ministry of Universities [FPU20/00450]. | es_ES |
dc.description.abstract | This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI andWeb of Science. Through our search, we found literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules’ occlusion by crystals’ precipitation contributing to improved sealing efficacy of restorations. Loading dentin adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrixmetalloproteinases (MMPs), contributing to dentin matrix stabilization. Zinc may not only act as a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin. | es_ES |
dc.description.sponsorship | Ministry of Economy and Competitiveness | es_ES |
dc.description.sponsorship | European Commission PID2020-114694RB-100 MINECO/AEI/FEDER/UE | es_ES |
dc.description.sponsorship | Ministry of Universities FPU20/00450 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Zinc | es_ES |
dc.subject | Adhesive | es_ES |
dc.subject | Polymers | es_ES |
dc.subject | Dentin | es_ES |
dc.subject | Remineralization | es_ES |
dc.subject | Degradation | es_ES |
dc.subject | Interface | es_ES |
dc.title | Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/polym14030642 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |