Injectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation
Metadatos
Afficher la notice complèteAuteur
Mañas Torres, María del Carmen; Gila Vilchez, Cristina; Vázquez Pérez, Francisco Jesús; Blanco Elices, Cristina; Rodríguez, Ismael Ángel; Alaminos Mingorance, Miguel; Álvarez Cienfuegos Rodríguez, Luis; López López, Modesto TorcuatoEditorial
American Chemical Society
Materia
Peptides Hybrid hydrogels Biomaterials Magnetic nanoparticles Self-assembly Tissue engineering Regenerative medicine
Date
2021-10-14Referencia bibliográfica
ACS Appl. Mater. Interfaces 2021, 13, 49692−49704. [https://doi.org/10.1021/acsami.1c13972]
Patrocinador
Instituto de Salud Carlos III FIS PI20/0317 ICI19/00024; European Commission; FSE "El FSE invierte en tu futuro", Spain; French National Research Agency (ANR) ANR-15-IDEX-01; Universidad de Granada/CBUA; FIS2017-85954-R MCIN/AEI/10.13039/501100011033/FEDER PE-0395-2019 PPJIB2020.07 PRE2018-083773 MCIN/AEI/10.13039/501100011033 FPU17/00491Résumé
The inclusion of magnetic nanoparticles (MNP) in a
hydrogel matrix to produce magnetic hydrogels has broadened the scope
of these materials in biomedical research. Embedded MNP offer the
possibility to modulate the physical properties of the hydrogel remotely
and on demand by applying an external magnetic field. Moreover, they
enable permanent changes in the mechanical properties of the hydrogel,
as well as alterations in the micro- and macroporosity of its threedimensional
(3D) structure, with the associated potential to induce
anisotropy. In this work, the behavior of biocompatible and
biodegradable hydrogels made with Fmoc-diphenylalanine (Fmoc-FF)
(Fmoc = fluorenylmethoxycarbonyl) and Fmoc−arginine−glycine−
aspartic acid (Fmoc-RGD) short peptides to which MNP were
incorporated was studied in detail with physicochemical, mechanical, and biological methods. The resulting hybrid hydrogels
showed enhance mechanical properties and withstood injection without phase disruption. In mice, the hydrogels showed faster and
improved self-healing properties compared to their nonmagnetic counterparts. Thanks to these superior physical properties and
stability during culture, they can be used as 3D scaffolds for cell growth. Additionally, magnetic short-peptide hydrogels showed
good biocompatibility and the absence of toxicity, which together with their enhanced mechanical stability and excellent injectability
make them ideal biomaterials for in vivo biomedical applications with minimally invasive surgery. This study presents a new
approach to improving the physical and mechanical properties of supramolecular hydrogels by incorporating MNP, which confer
structural reinforcement and stability, remote actuation by magnetic fields, and better injectability. Our approach is a potential
catalyst for expanding the biomedical applications of supramolecular short-peptide hydrogels.