A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
Metadatos
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Elsevier
Materia
Human biomonitoring Regulatory risk assessment Data value chain Data governance Harmonisation Registry
Date
2021-09-25Referencia bibliográfica
Maryam Zare Jeddi... [et al.]. A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles, International Journal of Hygiene and Environmental Health, Volume 238, 2021, 113826, ISSN 1438-4639, [https://doi.org/10.1016/j.ijheh.2021.113826]
Résumé
Data generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable
opportunities to support and advance regulatory risk assessment and management of chemicals in occupational
and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively
(reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data
collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the
solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, hostindependent
HBM registry framework based on the use of harmonised open-access protocol templates from
designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This
framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data
management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain.
Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation
within environmental health.
The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study
protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies.
Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It
is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence,
data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would
enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their
results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists,
risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk
from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European
initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the
development of the HBM GRF.