Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats
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Robles Vera, Iñaki; de la Visitación, Néstor; Toral, Marta; Sánchez Santos, Manuel; Romero Pérez, Miguel; Gómez Guzmán, Manuel; Vargas Palomares, José Félix; Duarte Pérez, Juan Manuel; Jiménez Moleón, RosarioEditorial
MDPI
Materia
Doxycycline Gut dysbiosis Hypertension Oxidative stress Inflammation (Deoxycorticosterone acetate) DOCA-salt model
Date
2021Referencia bibliográfica
Robles-Vera, I.; de la Visitación, N.; Toral, M.; Sánchez, M.; Romero, M.; Gómez-Guzmán, M.; Vargas, F.; Duarte, J.; Jiménez, R. Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats. Nutrients 2021, 13, 2971. https:// doi.org/10.3390/nu13092971
Sponsorship
Grants from Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad (SAF2017-84894-R); Ministerio de Ciencia e Innovación (PID2020-116347RB-I00); Junta de Andalucía (CTS-164, P20_00193); European Union, and by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV; Ciberes); Instituto de Salud Carlos III (Sara Borrell Program); European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”)Abstract
Previous experiments in animals and humans show that shifts in microbiota and its
metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX,
a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and
attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model
of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt
hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure,
improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX
decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier
integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta.
These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial
effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase
in blood pressure in this low-renin form of hypertension.