The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain
Metadatos
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MDPI
Materia
Prostate cancer Prolonged nighttime fasting Early time-restricted feeding Circadian rhythms Breakfast Chrononutrition
Fecha
2021-07-30Referencia bibliográfica
Palomar-Cros, A... [et al.]. The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain. Nutrients 2021, 13, 2662. [https://doi.org/10.3390/nu13082662]
Patrocinador
Instituto de Salud Carlos III European Commission FIS PI11/01889; MINECO (Ministry of Economy in Spain) fellowship; Spanish State Research Agency CEX2018-000806-S; Ministry of Science and Innovation through the "Centro de Excelencia Severo Ochoa 2019-2023" Program CEX2018-000806-S; Generalitat de Catalunya through the CERCA ProgramResumen
Nighttime fasting has been inconclusively associated with a reduced risk of cancer. The
purpose of this study was to investigate this association in relation to prostate cancer risk. We examined
data from 607 prostate cancer cases and 848 population controls who had never worked in
night shift work from the Spanish multicase-control (MCC) study, 2008–2013. Through an interview,
we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and
95% confidence intervals (CI) with unconditional logistic regression. After controlling for time of
breakfast, fasting for more than 11 h overnight (the median duration among controls) was associated
with a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95%
0.54–1.07). Combining a long nighttime fasting and an early breakfast was associated with a lower
risk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI
0.27–1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfast
may be associated with a lower risk of prostate cancer. Findings should be interpreted cautiously
and add to growing evidence on the importance of chrononutrition in relation to cancer risk.