Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products
Metadatos
Afficher la notice complèteEditorial
John Wiley & Sons
Materia
Bacterial DNA Bisphenol A Chron's disease Cytokine Short-chain fatty acids
Date
2021-06-04Referencia bibliográfica
Linares, R... [et al.]. Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products. The FASEB Journal. 2021; 35:e21697. [https://doi.org/10.1096/fj.202100481R]
Patrocinador
Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain PID2019-107036RB-I00 FPU 18/00063; IIS ISABIAL, Hospital General Universitario, Alicante, Spain 2020-0287Résumé
The relevance of environmental triggers in Crohn's disease remains poorly explored,
despite the well-known
association between industrialization and disease onset/progression.
We have aimed at evaluating the influence of endocrine disrupting chemicals
in CD patients. We performed a prospective observational study on consecutive
patients diagnosed of CD. Serum levels of endocrine disruptors, short-chain
fatty
acids, tryptophan and cytokines were measured. Bacterial-DNA
and serum endotoxin
levels were also evaluated. Gene expression of ER-α,
ER-β
and GPER was measured
in PBMCs. All patients were genotyped for NOD2 and ATG16L1 polymorphisms. A
series of 200 CD patients (140 in remission, 60 with active disease) was included in
the study. Bisphenol A was significantly higher in patients with active disease versus
remission and in colonic versus ileal disease. GPER was significantly increased in
active patients and correlated with BPA levels. BPA was significantly increased in
patients with bacterial-DNA
and correlated with serum endotoxin levels, (r = 0.417;
P = .003). Serum butyrate and tryptophan levels were significantly lower in patients
with bacterial-DNA
and an inverse relationship was present between them and BPA
levels (r = −0.491; P = .001) (r = −0.611; P = .001). Serum BPA levels correlated
with IL-23
(r = 0.807; P = .001) and IL-17A
(r = 0.743; P = .001). The multivariate
analysis revealed an independent significant contribution of BPA and bacterial-DNA
to serum levels of IL-23
and IL-17A.
In conclusion, bisphenol A significantly affects
systemic inflammatory response in CD patients with gut barrier disruption and dysbiotic
microbiota secretory products in blood. These results provide evidence of an
endocrine disruptor playing an actual pathogenic role on CD.