Phylogenetic Analysis of the 2020 West Nile Virus (WNV) Outbreak in Andalusia (Spain)
Metadatos
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Casimiro Soriguer, Carlos S.; Pedrosa Corral, Irene; Guillot Sulay, Vicente; Martínez González, Luis Javier; Navarro Marí, José María; Sanbonmatsu Gámez, SaraEditorial
MDPI
Materia
West Nile Virus Outbreak Meningoencephalitis Epidemiology Phylogeny Whole genome sequencing
Fecha
2021-05-05Referencia bibliográfica
Casimiro-Soriguer, C.S.; Perez-Florido, J.; Fernandez-Rueda, J.L.; Pedrosa-Corral, I.; Guillot-Sulay, V.; Lorusso, N.; Martinez-Gonzalez, L.J.; Navarro-Marí, J.M.; Dopazo, J.; Sanbonmatsu-Gámez, S. Phylogenetic Analysis of the 2020West Nile Virus (WNV) Outbreak in Andalusia (Spain). Viruses 2021, 13, 836. [https://doi.org/10.3390/v13050836]
Patrocinador
Instituto de Salud Carlos III PT17/0009/0006; European Commission; H2020 "ELIXIR-EXCELERATE fast-track ELIXIR implementation and drive early user exploitation across the life sciences" 676559Resumen
During recent decades West Nile Virus (WNV) outbreaks have continuously occurred in the Mediterranean area. In August 2020 a new WNV outbreak affected 71 people with meningoencephalitis in Andalusia and six more cases were detected in Extremadura (south-west of Spain), causing a total of eight deaths. The whole genomes of four viruses were obtained and phylogenetically analyzed in the context of recent outbreaks. The Andalusian viral samples belonged to lineage 1 and were relatively similar to those of previous outbreaks which occurred in the Mediterranean region. Here we present a detailed analysis of the outbreak, including an extensive phylogenetic study. As part on this effort, we implemented a local Nextstrain server, which has become a constituent piece of regional epidemiological surveillance, wherein forthcoming genomes of environmental samples or, eventually, future outbreaks, will be included.