Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study
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Show full item recordEditorial
Nature Research
Date
2021-02-04Referencia bibliográfica
Seral-Cortes, M., Sabroso-Lasa, S., De Miguel-Etayo, P., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., ... & Labayen, I. (2021). Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study. Scientific reports, 11(1), 1-11. [https://doi.org/10.1038/s41598-021-82712-4]
Sponsorship
European Commission FOOD-CT-2005-007034; HELENA project; Spanish Ministry of Economy and Competitiveness RYC-2010-05957 RYC2011-09011; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn); Iberus Talent Pre-doctoral fellowships under the European Union 801586; Instituto de Salud Carlos III CB15/00043Abstract
Obesity is the result of interactions between genes and environmental factors. Since monogenic
etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful
to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a
GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A
total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in
Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample
was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single
nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with
obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model.
Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS
(wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was
calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and
wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially
be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in
European adolescents.