Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
Metadatos
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Nature Research
Date
2021-02-17Referencia bibliográfica
Lapresta-Fernández, A., Salinas-Castillo, A., & Capitán-Vallvey, L. F. (2021). Synthesis of a thermoresponsive crosslinked MEO 2 MA polymer coating on microclusters of iron oxide nanoparticles. Scientific reports, 11(1), 1-8. [
Patrocinador
Andalusian Knowledge Agency; European Commission 291780; Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía; Spanish "Ministerio de Economía y Competitividad" PID2019-103938RB-I00 CTQ2017-86125-P; Junta de Andalucía B-FQM-243-UGR18 P18-RT-2961; CEI-Biotic CEI2013-MP-10Résumé
Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (
Fe3O4) with a thermopolymeric
shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully
developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the
functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence
of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a
covalent attachment of the P(MEO2MA) shell on the surface of the MNPs while a crosslinked network
is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization
synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume
until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm
in diameter) between 9 and 49 °C. The hybrid Fe3O4@
P(MEO2MA) microgel exhibits a lower critical
solution temperature of 21.9 °C below the corresponding value for P(MEO2MA) (bulk, 26 °C). The
MEO2MA
coating performance in the hybrid microgel is characterized by dynamic light scattering and
transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel]
was established by thermogravimetric analysis while magnetic properties by vibrating sample
magnetometry.