Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit
Metadatos
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Bmc
Materia
Chickens Eggshell Calcite Biomineralization Ion supply Matrix protein functions Amorphous calcium carbonate Extracellular vesicles
Date
2021-02-12Referencia bibliográfica
Gautron, J., Stapane, L., Le Roy, N., Nys, Y., Rodriguez-Navarro, A. B., & Hincke, M. T. (2021). Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit. BMC molecular and cell biology, 22(1), 1-17. [https://doi.org/10.1186/s12860-021-00350-0]
Patrocinador
French National Research Agency (ANR) European Commission ANR-13-BSV-0007-01; Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2016-04410; Le STUDIUM; Centre Val de Loire, Nouzilly, France - University of ToursRésumé
The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its
formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds of proteins that
interact with the mineral phase controlling its formation and structural organization, and thus determine the
mechanical properties of the mature biomaterial. We describe its mineralogy, structure and the regulatory
interactions that integrate the mineral and organic constituents. We underline recent evidence for vesicular transfer
of amorphous calcium carbonate (ACC), as a new pathway to ensure the active and continuous supply of the ions
necessary for shell mineralization. Currently more than 900 proteins and thousands of upregulated transcripts have
been identified during chicken eggshell formation. Bioinformatic predictions address their functionality during the
biomineralization process. In addition, we describe matrix protein quantification to understand their role during the
key spatially- and temporally- regulated events of shell mineralization. Finally, we propose an updated scheme with
a global scenario encompassing the mechanisms of avian eggshell mineralization. With this large dataset at hand, it
should now be possible to determine specific motifs, domains or proteins and peptide sequences that perform a
critical function during avian eggshell biomineralization. The integration of this insight with genomic data (nonsynonymous
single nucleotide polymorphisms) and precise phenotyping (shell biomechanical parameters) on pure
selected lines will lead to consistently better-quality eggshell characteristics for improved food safety. This
information will also address the question of how the evolutionary-optimized chicken eggshell matrix proteins
affect and regulate calcium carbonate mineralization as a good example of biomimetic and bio-inspired material
design.