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Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury
dc.contributor.author | Bravo Caparrós, Inmaculada | |
dc.contributor.author | Ruiz Cantero, María del Carmen | |
dc.contributor.author | Perazzoli, Gloria | |
dc.contributor.author | Cronin, SFJ | |
dc.contributor.author | Vela, José Miguel | |
dc.contributor.author | Hamed, MF | |
dc.contributor.author | Penninger, JM | |
dc.contributor.author | Baeyens Cabrera, José Manuel | |
dc.contributor.author | Cobos del Moral, Enrique José | |
dc.contributor.author | Nieto López, Francisco Rafael | |
dc.date.accessioned | 2021-03-11T08:12:48Z | |
dc.date.available | 2021-03-11T08:12:48Z | |
dc.date.issued | 2020-04 | |
dc.identifier.citation | Bravo-Caparrós I, Ruiz-Cantero MC, Perazzoli G, Cronin SJF, Vela JM, Hamed MF, Penninger JM, Baeyens JM, Cobos EJ, Nieto FR. Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J. 2020 Apr;34(4):5951-5966. | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/67088 | |
dc.description.abstract | Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by DRG neurons but its role in neuropathic pain is not fully understood. We investigated the effect of peripheral Sig-1R on neuroinflammation in the DRG after spared (sciatic) nerve injury (SNI) in mice. Nerve injury induced a decrease in NeuN staining along with the nuclear eccentricity and ATF3 expression in the injured DRG. Sig-1R was present in all DRG neurons examined, and after SNI this receptor translocated to the periphery of the soma and the vicinity of the nucleus, especially in injured ATF3 + neurons. In WT mice, injured DRG produced the chemokine CCL2, and this was followed by massive infiltration of macrophages/monocytes, which clustered mainly around sensory neurons with translocated Sig-1R, accompanied by robust IL-6 increase and mechanical allodynia. In contrast, Sig-1R knockout (Sig-1R-KO) mice showed reduced levels of CCL2, decreased macrophage/monocyte infiltration into DRG, and less IL-6 and neuropathic mechanical allodynia after SNI. Our findings point to an important role of peripheral Sig-1R in sensory neuron-macrophage/monocyte communication in the DRG after peripheral nerve injury; thus, these receptors may contribute to the neuropathic pain phenotype | es_ES |
dc.description.sponsorship | Neurofarmacología del dolor de la Universidad de Granada (CTS-109) | es_ES |
dc.description.sponsorship | FPU grants from the Spanish Ministry of Education, Culture and Sports. | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness (MINECO, grant SAF2016-80540-R) | es_ES |
dc.description.sponsorship | the Junta de Andalucía (grant CTS 109) | es_ES |
dc.description.sponsorship | Esteve Pharmaceuticals | es_ES |
dc.description.sponsorship | European Regional Development Fund (ERDF) | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | ATF3 | es_ES |
dc.subject | CCL2 | es_ES |
dc.subject | IL-6 | es_ES |
dc.subject | Neuroinflammation | es_ES |
dc.subject | Spared nerve injury | es_ES |
dc.subject | Sigma-1 receptor | es_ES |
dc.subject | Neuropathic pain | es_ES |
dc.title | Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.projectID | MINECO, grant SAF2016-80540-R | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1096/fj.201901921R | |
dc.type.hasVersion | info:eu-repo/semantics/submittedVersion | es_ES |