Risk Factors for Short-Term Lung Cancer Survival
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Caballero Vázquez, Alberto; Romero Béjar, José Luis; Albendín García, Luis; Suleiman Martos, Nora; Gómez Urquiza, Jose Luis; Cañadas De La Fuente, Gustavo Raúl; Cañadas De La Fuente, Guillermo ArturoEditorial
MDPI
Materia
Epidemiological risk factors Logistic regression Lung cancer Short-termsurvival Treatment
Date
2021-02-01Referencia bibliográfica
Caballero-Vázquez, A.; Romero-Béjar, J.L.; Albendín-García, L.; Suleiman-Martos, N.; Gómez-Urquiza, J.L.; Cañadas, G.R.; Cañadas-De la Fuente, G.A. Risk Factors for Short-Term Lung Cancer Survival. J. Clin. Med. 2021, 10, 519. [https://doi.org/10.3390/jcm10030519]
Abstract
Background: Lung cancer is typically diagnosed in an advanced phase of its natural history.
Explanatory models based on epidemiological and clinical variables provide an approximation of
patient survival less than one year using information extracted from the case history only, whereas
models involving therapeutic variables must confirm that any treatment applied is worse than surgery
in survival terms. Models for classifying less than one year survival for patients diagnosed with lung
cancer which are able to identify risk factors and quantify their effect for prognosis are analyzed.
Method: Two stepwise binary logistic regression models, based on a retrospective study of 521 cases
of patients diagnosed with lung cancer in the Interventional Pneumology Unit at the Hospital “Virgen
de las Nieves”, Granada, Spain. Results: The first model included variables age, history of pulmonary
neoplasm, tumor location, dyspnea, dysphonia, and chest pain. The independent risk factors age
greater than 70 years, a peripheral location, dyspnea and dysphonia were significant. For the second
model, treatments were also significant. Conclusions: Age, history of pulmonary neoplasm, tumor
location, dyspnea, dysphonia, and chest pain are predictors for survival in patients diagnosed with
lung cancer at the time of diagnosis. The treatment applied is significant for classifying less than
one year survival time which confirms that any treatment is markedly inferior to surgery in terms of
survival. This allows to consider applications of more or less aggressive treatments, anticipation of
palliative cares or comfort measures, inclusion in clinical trials, etc.