Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer
Metadatos
Mostrar el registro completo del ítemAutor
Mesas Hernández, Cristina; Martínez, Rosario; Ortiz Quesada, Raúl; Galisteo Moya, Milagros; López-Jurado Romero De La Cruz, María; Cabeza, Laura; Perazzoli, Gloria; Melguizo Alonso, Consolación; Porres Foulquie, Jesús María; Prados Salazar, José CarlosEditorial
MDPI
Materia
Colon cancer Euphorbia lathyris Ethanolic extract Apoptosis Antiangiogenic effect Cancer stem cells
Fecha
2021Referencia bibliográfica
Mesas, C.; Martínez, R.; Ortíz, R.; Galisteo, M.; López-Jurado, M.; Cabeza, L.; Perazzoli, G.; Melguizo, C.; Porres, J.M.; Prados, J. Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer. Nutrients 2021, 13, 566. https:// doi.org/10.3390/nu13020566
Patrocinador
Granada University (project PSE/17/002), Ministerio de Ciencia e Innovación (project RTC-2017-6540-1) and by the CTS-107 and AGR145 Groups.Resumen
The seeds of Euphorbia lathyris have been used in traditional medicine to treat various
medical conditions. However, neither all of their active biocompounds nor the molecular mechanisms
underlying their therapeutic effects have been described. A new ethanolic extract of defatted flour
from mature seeds of Euphorbia lathyris showed a high total polyphenol content and significant
antioxidant activity. Chromatographic analysis showed that esculetin, euphorbetin, gaultherin, and
kaempferol-3-rutinoside were the most abundant polyphenolic bioactive compounds. Antiproliferative assays showed a high and selective antitumor activity against colon cancer cell lines (T84
and HCT-15). In addition, a significant antiproliferative activity against glioblastoma multiforme
cells was also demonstrated. Its mechanism of action to induce cell death was mediated by the
overexpression of caspases 9, 3, and 8, and by activation of autophagy. Interestingly, a reduction
in the migration capacity of colon cancer cells and a significant antiangiogenic effect on human
umbilical vein endothelial cells were also demonstrated. Finally, the extract significantly reduced the
subpopulations of cancer stem cells. This extract could be the basis to develop new therapeutic strategies for the treatment of colon cancer, although further experiments will be necessary to determine
its in vivo effects.