Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients
Metadatos
Afficher la notice complèteAuteur
Nestares Pleguezuelo, María Teresa; De la Flor Alemany, Marta; Bonavita, Antonela; Aparicio García-Molina, VirginiaEditorial
Mdpi
Materia
Celiac disease Ultra-processed foods Gluten-free diet Inflammatory signaling Oxidative stress Children
Date
2021-01-06Referencia bibliográfica
Nestares, T.; Martín-Masot, R.; Flor-Alemany, M.; Bonavita, A.; Maldonado, J.; Aparicio, V.A. Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients. Nutrients 2021, 13, 156. [https://doi.org/10.3390/nu13010156]
Patrocinador
Regional Government of Andalusia, Excellence Research Project P12-AGR-2581; University of Granada PP2017-PIP14; Spanish Ministry of Education, Culture and Sports FPU17/03715Résumé
The current study was designed to assess the influence of consumption of ultra-processed
(UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with
celiac disease (CD). The study included 85 children. The celiac group (n = 53) included children with
CD with a long (>18 months, n = 17) or recent (<18 months, n = 36) adherence to a gluten-free diet
(GFD). The control group (n = 32) included healthy children with a significantly lower consumption
of UPF compared to the CD group, both expressed as kcal/day (p = 0.043) and as percentage of
daily energy intake (p = 0.023). Among children with CD, the group with the lowest consumption
of UPF (below the 50% of daily energy intake) had a greater Mediterranean diet (MD) adherence
and higher moderate physical activity levels. In addition, CD children with the lowest consumption
of UPF had healthier redox (lower soluble superoxide dismutase-1 and 15-F2t-isoprostanes) and
inflammatory profiles (lower macrophage inflammatory protein-1 ) compared to the group with the
highest consumption of UPF (all, p < 0.05) regardless of the time on a GFD. These findings highlight
the importance of a correct monitoring of the GFD. An unbalanced GFD with high consumption
of UPF and an unhealthy pattern with less physical activity and worse adherence to MD results
in a worse inflammatory profile, which could act as a parallel pathway that could have important
consequences on the pathophysiology of the disease.