Study of the fetal and maternal microbiota in pregnant women with intrauterine growth restriction and its relationship with inflammatory biomarkers A case-control study protocol (SPIRIT compliant)
Metadatos
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Lippincott Williams & Wilkns
Fecha
2020-11-13Referencia bibliográfica
Fernandez-Gonzalez, S., Ortiz-Arrabal, O., Torrecillas, A., Pérez-Cruz, M., Chueca, N., Gómez-Roig, M. D., & Gómez-Llorente, C. (2020). Study of the fetal and maternal microbiota in pregnant women with intrauterine growth restriction and its relationship with inflammatory biomarkers: A case-control study protocol (SPIRIT compliant). Medicine, 99(46). [http://dx.doi.org/10.1097/MD.0000000000022722]
Patrocinador
Instituto de Salud Calos III; Fondos de Desarrollo Regional Europeos (FEDER) PI17/01215Resumen
In general terms, fetal growth restriction (FGR) is considered the impossibility of achieving the genetically determined potential size. In
the vast majority of cases, it is related to uteroplacental insufficiency. Although its origin remains unknown and causes are only known
in 30% of cases, it is believed to be related to an interaction of environmental and genetic factors with either a fetal or maternal origin.
One hypothesis is that alterations in the gastrointestinal microbiota composition, and thus alteration in the immune response, could
play a role in FGR development. We performed an observational, prospective study in a subpopulation affected with FGR to elucidate
the implications of this microbiota on the FGR condition.
A total of 63 fetuses with FGR diagnosed in the third trimester as defined by the Delphi consensus, and 63 fetuses with fetal growth
appropriate for gestational age will be recruited. Obstetric and nutritional information will be registered by means of specific
questionnaires. We will collect maternal fecal samples between 30 to 36 weeks, intrapartum samples (maternal feces, maternal and
cord blood) and postpartum samples (meconium and new-born feces at 6 weeks of life). Samples will be analyzed in the Department
of Biochemistry and Molecular Biology II, Nutrition and Food Technology Institute of the University of Granada (UGR), for the
determination of the gastrointestinal microbiota composition and its relationship with inflammatory biomarkers.
This study will contribute to a better understanding of the influence of gastrointestinal microbiota and related inflammatory
biomarkers in the development of FGR.
Trial registration: NCT04047966. Registered August 7, 2019, during the recruitment stage. Retrospectively registered. Ongoing
research.