Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?
Metadata
Show full item recordEditorial
SAGE PUBLICATIONS INC
Materia
Metabolic syndrome Oxidative stress Periodontitis Hypertension Dyslipidemia Insulin-resistance
Date
2009Referencia bibliográfica
Bullon, P., Morillo, J. M., Ramirez-Tortosa, M. C., Quiles, J. L., Newman, H. N., & Battino, M. (2009). Metabolic syndrome and periodontitis: Is oxidative stress a common link? Journal of Dental Research, 88(6), 503-518. doi:10.1177/0022034509337479
Sponsorship
Universita Politecnica delle Marche, Italy; Grupo de investigacion CTS113 Junta de Andalucia, SpainAbstract
A review of pathological mechanisms that can
explain the relationship between periodontitis
and cardiovascular disease (CVD) is necessary to
improve the management of both conditions.
Metabolic syndrome is a combination of obesity,
hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia, and dyslipidemia. All these
have been examined in recent years in terms of their
relationship to periodontitis. Reviewed data indicate
an association between some of them (body mass
index, high-density lipoprotein-cholesterol [HDL-C],
triglycerides, high blood pressure, among others)
and periodontitis. Oxidative stress may act as a
potential common link to explain relationships
between each component of metabolic syndrome
and periodontitis. Both conditions show increased
serum levels of products derived from oxidative
damage, with a pro-inflammatory state likely influencing each other bidirectionally. Adipocytokines
might modulate the oxidant/anti-oxidant balance in
this relationship.