Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis
Metadatos
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ELSEVIER
Materia
Periodontitis CoQ Mitochondrial membrane potential Apoptosis Reactive oxygen species Cardiovascular disease Free radicals
Date
2011Referencia bibliográfica
Bullon, P., David Cordero, M., Luis Quiles, J., Manuel Morillo, J., del Carmen Ramirez-Tortosa, M., & Battino, M. (2011). Mitochondrial dysfunction promoted by porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis. Free Radical Biology and Medicine, 50(10), 1336-1343. [doi: 10.1016/j.freeradbiomed.2011.02.018]
Résumé
Oxidative stress is one of the factors that could explain the pathophysiological mechanism of inflammatory
conditions that occur in cardiovascular disease (CVD) and periodontitis. Such inflammatory response is often
evoked by specific bacteria, as the lipopolysaccharide (LPS) of Porphyromonas gingivalis is a key factor in this
process. The aim of this research was to study the role of mitochondrial dysfunction in peripheral blood
mononuclear cells (PBMCs) from periodontitis patients and to evaluate the influence of LPS on fibroblasts to
better understand the pathophysiology of periodontitis and its relationship with CVD. PBMCs from patients
showed lower CoQ10 levels and citrate synthase activity, together with high levels of ROS production. LPS-treated
fibroblasts provoked increased oxidative stress and mitochondrial dysfunction by a decrease in mitochondrial
protein expression, mitochondrial mass, and mitochondrial membrane potential. Our study supports the
hypothesis that LPS-mediated mitochondrial dysfunction could be at the origin of oxidative stress in periodontal
patients. Abnormal PBMC performance may promote oxidative stress and alter cytokine homeostasis. In
conclusion, mitochondrial dysfunction could represent a possible link to understanding the interrelationships
between two prominent inflammatory diseases: periodontitis and CVD.