Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations
Metadatos
Mostrar el registro completo del ítemAutor
Pedrosa-Rivera, María; Praena Rodríguez, Antonio Javier; Porras Sánchez, José Ignacio; Sabariego Quintanilla, Manuel; Álvarez, Patricia; Ruiz Ruiz, María Carmen; Ruiz Magaña, María JoséEditorial
MDPI
Materia
Boron Neutron Capture Therapy Relative biological effectiveness Thermal neutrons
Fecha
2020Referencia bibliográfica
Pedrosa-Rivera M, Praena J, Porras I, Sabariego MP, Köster U, Haertlein M, Forsyth VT, Ramírez JC, Jover C, Jimena D, Osorio JL, Álvarez P, Ruiz-Ruiz C, Ruiz-Magaña MJ. Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations. Cells. 2020; 9(10):2144. [https://doi.org/10.3390/cells9102144]
Patrocinador
Asociacion Espanola Contra el Cancer (AECC) PS16163811PORR; Spanish MINECO FIS2015-69941-C2-1-P; Junta de Andalucia P11-FQM-8229; Campus of International Excellence BioTic P-BS-64; University of Granada Chair Neutrons for Medicine: the Spanish Fundacion ACS; Asociacion Capitan Antonio; Fundacion ACS; La Kuadrilla de Iznalloz; Sonriendo Se Puede GanarResumen
The experimental determination of the relative biological effectiveness of thermal neutron
factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained
while using mixed beams that consist of both neutrons and photons of various energies. A common
weighting factor has been used for both thermal and fast neutron doses, although such an approach has
been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam
has been used to determine thermal neutron relative biological effectiveness factors. Different cancer
cell lines, which correspond to glioblastoma, melanoma, and head and neck squamous cell carcinoma,
and non-tumor cell lines (lung fibroblast and embryonic kidney), have been irradiated while using
an experimental arrangement designed to minimize neutron-induced secondary gamma radiation.
Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference
data for comparison with that from neutron irradiation. The survival and proliferation were studied
after irradiation, yielding the Relative Biological Effectiveness that corresponds to the damage of
thermal neutrons for the different tissue types.