Cancer stem cell secretome in the tumor microenvironment: a key point for an efective personalized cancer treatment
Metadatos
Afficher la notice complèteEditorial
BMC
Materia
Cancer stem cells Tumor Microenvironment Secretome Growth factors Interleukins miRNAs Exosomes
Date
2020Referencia bibliográfica
López de Andrés, J., Griñán-Lisón, C., Jiménez, G. et al. Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment. J Hematol Oncol 13, 136 (2020). [https://doi.org/10.1186/s13045-020-00966-3]
Patrocinador
Junta de Andalucia PIN-0224-2019; Ministerio de Ciencia, Innovacion y Universidades RTI2018-101309-B-C22; Consejeria de Economia, Conocimiento, Empresas y Universidad de la Junta de Andalucia (FEDER Funds) P18-FR-2470 SOMM17/6109/UGR; Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (FEDER funds) PIE16/00045 DTS19/00143 DTS17/00087; Chair "Doctors Galera-Requena in cancer stem cell research" CMC-CTS963Résumé
Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis and resistance to chemoand radiotherapy, ultimately leading to tumor relapse. As a consequence, the detection and eradication of this cell
subpopulation represent a current challenge in oncology medicine. CSC phenotype is dependent on the tumor
microenvironment (TME), which involves stem and diferentiated tumor cells, as well as diferent cell types, such as
mesenchymal stem cells, endothelial cells, fbroblasts and cells of the immune system, in addition to the extracellular
matrix (ECM), diferent in composition to the ECM in healthy tissues. CSCs regulate multiple cancer hallmarks through
the interaction with cells and ECM in their environment by secreting extracellular vesicles including exosomes, and
soluble factors such as interleukins, cytokines, growth factors and other metabolites to the TME. Through these fac‑
tors, CSCs generate and activate their own tumor niche by recruiting stromal cells and modulate angiogenesis, metas‑
tasis, resistance to antitumor treatments and their own maintenance by the secretion of diferent factors such as IL-6,
VEGF and TGF-ß. Due to the strong infuence of the CSC secretome on disease development, the new antitumor
therapies focus on targeting these communication networks to eradicate the tumor and prevent metastasis, tumor
relapse and drug resistance. This review summarizes for the frst time the main components of the CSC secretome
and how they mediate diferent tumor processes. Lastly, the relevance of the CSC secretome in the development of
more precise and personalized antitumor therapies is discussed.