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Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration
dc.contributor.author | Toledano Pérez, Manuel | |
dc.contributor.author | Asady, Samara | |
dc.contributor.author | Toledano Osorio, Manuel | |
dc.contributor.author | Benítez García, José A. | |
dc.contributor.author | Osorio Ruiz, Raquel | |
dc.date.accessioned | 2020-09-14T08:44:54Z | |
dc.date.available | 2020-09-14T08:44:54Z | |
dc.date.issued | 2020-06-04 | |
dc.identifier.citation | Toledano, M., Asady, S., Toledano-Osorio, M., García-Godoy, F., Serrera-Figallo, M. A., Benítez-García, J. A., & Osorio, R. (2020). Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration. Polymers, 12(6), 1290. [doi:10.3390/polym12061290] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/63407 | |
dc.description.abstract | Native collagen-based membranes are used to guide bone regeneration; but due to their rapid biodegradation, this treatment is often unpredictable. The purpose of this study was to investigate the biodegradability of natural collagen membranes. Three non-cross-linked resorbable collagen barrier membranes were tested: Derma Fina (porcine dermis), Evolution Standard (equine pericardium) and Duo-Teck (equine lyophilized collagen felt). 10 × 10 mm2 pieces of membranes were submitted to three different degradation procedures: (1) hydrolytic degradation in phosphate buffer solution, (2) enzyme resistance, using a 0.25% porcine trypsin solution, and (3) bacterial (Clostridium histolyticum) collagenase resistance test. Weight measurements were performed with an analytic microbalance. Thickness was measured with a digital caliper. Membranes were analyzed at different time-points, up to 21 d of immersion. A stereomicroscope was used to obtain membranes’ images. ANOVA and Student Newman Keuls were used for mean comparisons (p < 0.05), except when analyzing differences between time-points within the same membrane and solution where pair-wise comparisons were applied (p < 0.001). Derma Fina attained the highest resistance to all degradation challenges. Duo-Teck was the most susceptible membrane to degradation, complete degradation occurred as soon as 8 h. The bacterial collagenase solution performed as the most aggressive test as all membranes presented 100% degradation before 21 d. | es_ES |
dc.description.sponsorship | Ministry of Economy and Competitiveness from Spain MINECO/FEDER MAT2017-85999P | es_ES |
dc.description.sponsorship | European Union (EU) MINECO/FEDER MAT2017-85999P | es_ES |
dc.description.sponsorship | Regional Government of Andalusia Research Fund from Spain A-BIO-157-UGR-18 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Collagen | es_ES |
dc.subject | Membranes | es_ES |
dc.subject | Biodegradation | es_ES |
dc.subject | Bone regeneration | es_ES |
dc.title | Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | doi:10.3390/polym12061290 |