Neutrophil Extracellular Traps in Periodontitis
Metadatos
Mostrar el registro completo del ítemAutor
Magán Fernández, Antonio; Rasheed Al-Bakri, Sarmad Muayad; O'Valle Ravassa, Francisco Javier; Benavides Reyes, Cristina; Abadía Molina, Francisco; Mesa Aguado, Francisco LuisEditorial
MDPI
Materia
Innate immunity Periodontitis Neutrophil functions Neutrophil extracellular traps
Fecha
2020-06-19Referencia bibliográfica
Magán-Fernández, A., Rasheed Al-Bakri, S. M., O’Valle, F., Benavides-Reyes, C., Abadía-Molina, F., & Mesa, F. (2020). Neutrophil Extracellular Traps in Periodontitis. Cells, 9(6), 1494. [doi: 10.3390/cells9061494]
Resumen
Neutrophils are key cells of the immune system and have a decisive role in fighting foreign
pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA
enclosing antimicrobial peptides and histones that are released into extracellular space following
neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and
drugs. Neutrophils can remain functional after NET formation and are important for periodontal
homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state
between the gingival microbiome and the immune response of the host. The pathogenesis of
periodontitis includes an immune-inflammatory component in which impaired NET formation
and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the
destruction of gingival tissue. In this review, we summarize the current knowledge about the role of
NETs in the pathogenesis of periodontitis.