Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial
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Molina-Leyva, Ignacio; Molina Leyva, Alejandro; Riquelme Gallego, Blanca; Cano Ibáñez, Naomi; García Molina, Laura; Bueno Cavanillas, AuroraEditorial
MDPI
Materia
Mediterranean diet Dry eye Fatty acids Extra-virgin olive oil PREDIMED-PLUS trial
Date
2020-05Referencia bibliográfica
Molina-Leyva, I., Molina-Leyva, A., Riquelme-Gallego, B., Cano-Ibáñez, N., García-Molina, L., & Bueno-Cavanillas, A. (2020). Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial. Nutrients, 12(5), 1289. [DOI: 10.3390/nu12051289]
Sponsorship
Instituto de Salud Carlos III Spanish Government PI17/00764; European Union (EU)Abstract
The purpose of this study is to evaluate the effect of a Mediterranean diet supplemented with
extra virgin olive oil and nuts on dry eye parameters. The participants in this study were randomized
into one of the two interventional arms: (1) a standard intervention group, a Mediterranean diet
supplemented with extra virgin olive oil and nuts; and (2) an intensive intervention group, based
on a hypocaloric Mediterranean diet and an intensive lifestyle program with physical activity and
weight-loss goals. In both groups, common dry eye tests were conducted at baseline and after six
months: the Ocular Surface Disease Index (OSDI), the Dry Eye Scoring System (DESS), tear break-up
time (TBUT), the Schirmer’s test, and the Oxford staining grade. Sixty-seven eyes were examined.
After six months, dry eye parameters improved in both groups; differences between groups were
favorable for the intensive intervention group. The implementation of a Mediterranean diet pattern
was beneficial for the selected patients with dry eye, and could be beneficial for patients with dry eye
in general. Behavioral support for diet adherence and the promotion of healthy lifestyles (exercise)
and weight loss (calorie restriction) have an added positive effect.