Clinical and Neurophysiological Correlates of Emotion and Food Craving Regulation in Patients with Anorexia Nervosa
Metadatos
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MDPI
Materia
Food craving Food addiction Emotion Regulation Eating disorders Anorexia nervosa Event-related potentials (ERPs) EEG Neurophysiology Psychopathology
Fecha
2020-03-31Referencia bibliográfica
Mallorquí-Bagué, N., Lozano-Madrid, M., Testa, G., Vintró-Alcaraz, C., Sánchez, I., Riesco, N., ... & Granero, R. (2020). Clinical and neurophysiological correlates of emotion and food craving regulation in patients with anorexia nervosa. Journal of Clinical Medicine, 9(4), 960. [doi:10.3390/jcm9040960]
Patrocinador
This manuscript and research were supported by grants from the Instituto de Salud Carlos III (ISCIII) [FIS PI14/00290, PI17/01167 and cofounded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe]. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) is an initiative of ISCIII. M.L-M and C.V-A are supported by a predoctoral grants of the Ministerio de Educacion, Cultura y Deporte (FPU15/02911 and FPU16/01453). Study resulting from the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya by the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut". We thank CERCA Programme/Generalitat de Catalunya for Institutional support.Resumen
Background: Difficulties in emotion regulation and craving regulation have been linked to
eating symptomatology in patients with anorexia nervosa (AN), contributing to the maintenance
of their eating disorder. Methods: To investigate clinical and electrophysiological correlates of
these processes, 20 patients with AN and 20 healthy controls (HC) completed a computerized task
during EEG recording, where they were instructed to down-regulate negative emotions or food
craving. Participants also completed self-report measures of emotional regulation and food addiction.
The P300 and Late Positive Potential (LPP) ERPs were analysed. Results: LPP amplitudes were
significantly smaller during down-regulation of food craving among both groups. Independent of
task condition, individuals with AN showed smaller P300 amplitudes compared to HC. Among HC,
the self-reported use of re-appraisal strategies positively correlated with LPP amplitudes during
emotional regulation task, while suppressive strategies negatively correlated with LPP amplitudes.
The AN group, in comparison to the HC group, exhibited greater food addiction, greater use of
maladaptive strategies, and emotional dysregulation. Conclusions: Despite the enhanced self-reported
psychopathology among AN, both groups indicated neurophysiological evidence of food craving regulation as evidenced by blunted LPP amplitudes in the relevant task condition. Further research
is required to delineate the mechanisms associated with reduced overall P300 amplitudes among
individuals with AN.