Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old
Metadatos
Afficher la notice complèteAuteur
Nieto-Ruiz, Ana; Diéguez Castillo, Estefanía; Sepúlveda Valbuena, Natalia; Catena, Elvira; Jiménez, Jesús; Rodríguez-Palmero, Maria; Catena Martínez, Andrés; Miranda León, María Teresa; García Santos, José Antonio; G. Bermúdez, Mercedes; Campoy Folgoso, CristinaEditorial
MDPI
Materia
Infant formula Functional nutrients Breastfeeding Language development
Date
2020-02-19Referencia bibliográfica
Nieto-Ruiz, A., Diéguez, E., Sepúlveda-Valbuena, N., Catena, E., Jiménez, J., Rodríguez-Palmero, M., ... & Campoy, C. (2020). Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old. Nutrients, 12(2), 535.
Patrocinador
This project has been funded by Ordesa Laboratories, S.L. Contract University of Granada General Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No. 4003, Spanish Ministry of Economy, Industry and Competitiveness; funded in part by HORIZON 2020 EU DynaHEALTH Project (GA No.633595). Natalia Sepúlveda-Valbuena has been granted with a scholarship from Fundación Carolina, Madrid, SpainRésumé
Nutrition during early life is essential for brain development and establishes the basis
for cognitive and language skills development. It is well established that breastfeeding, compared
to formula feeding, has been traditionally associated with increased neurodevelopmental scores
up to early adulthood. We analyzed the long-term effects of a new infant formula enriched with
bioactive compounds on healthy children’s language development at four years old. In a randomized
double-blind COGNIS study, 122 children attended the follow-up call at four years. From them,
89 children were fed a standard infant formula (SF, n = 46) or an experimental infant formula enriched
with functional nutrients (EF, n = 43) during their first 18 months of life. As a reference group,
33 exclusively breastfed (BF) were included. Language development was assessed using the Oral
Language Task of Navarra-Revised (PLON-R). ANCOVA, chi-square test, and logistic regression
models were performed. EF children seemed to show higher scores in use of language and oral
spontaneous expression than SF children, and both SF and EF groups did not differ from the BF group.
Moreover, it seems that SF children were more frequently categorized into “need to improve and
delayed” in the use of language than EF children, and might more frequently present “need to improve
and delayed” in the PLON-R total score than BF children. Finally, the results suggest that SF children
presented a higher risk of suffering language development than BF children. Secondary analysis also
showed a slight trend between low socioeconomic status and poorer language skills. The functional
compound-enriched infant formula seems to be associated with beneficial long-term effects in the
development of child’s language at four years old in a similar way to breastfed infants.