Maternal and paternal preconception exposure to phenols and preterm birth
Metadata
Show full item recordAuthor
Mustieles Miralles, VicenteEditorial
Elsevier Inc.
Materia
Preterm birth Bisphenol Paraben Benzophenone Preconception
Date
2020-02-29Referencia bibliográfica
Mustieles, V., Zhang, Y., Yland, J., Braun, J. M., Williams, P. L., Wylie, B. J., ... & Hauser, R. (2020). Maternal and paternal preconception exposure to phenols and preterm birth. Environment International, 137, 105523.
Abstract
Background: Phenol exposure during pregnancy has been associated with preterm birth, but the potential effect
of preconception exposure in either parent is unknown. There is a growing body of evidence to suggest that the
preconception period is a critical window of vulnerability for adverse pregnancy outcomes.
Objective: We examined whether maternal and paternal preconception urinary concentrations of select phenols
were associated with the risk of preterm birth among couples attending fertility care. Results: The mean (SD) gestational age among singletons was 39.3 (1.7) weeks with 8% born preterm. A natural
log-unit increase in maternal preconception BPA (RR 1.94; 95% CI: 1.20, 3.14) and BPS (RR 2.42; 95% CI: 1.01,
5.77) concentration was associated with an increased risk of preterm birth. These associations remained after
further adjustment for maternal prenatal and paternal preconception biomarker concentrations. Paternal preconception
ΣParabens concentrations showed a possible elevated risk of preterm birth (RR 1.36; 95% CI: 0.94,
1.96). No consistent pattern of association was observed for benzophenone-3 or triclosan biomarkers in either
parent.
Discussion: Maternal preconception urinary BPA and BPS concentrations, as well as paternal preconception
urinary parabens concentrations were prospectively associated with a higher risk of preterm birth. Subfertile
couples’ exposure to select phenols during the preconception period may be an unrecognized risk factor for
adverse pregnancy outcomes.