Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy
Metadatos
Mostrar el registro completo del ítemAutor
Contreras Cáceres, Rafael; Cabeza, Laura; Perazzoli, Gloria; Díaz, Amelia; López Romero, Juan Manuel; Melguizo Alonso, Consolación; Prados Salazar, José CarlosEditorial
MDPI
Materia
Electrospun nanofibers Cancer treatment Drug release Nanomedicine Biocompatible polymers Hyperthermia
Fecha
2019-04-24Referencia bibliográfica
Contreras-Cáceres, R., Cabeza, L., Perazzoli, G., Díaz, A., López-Romero, J. M., Melguizo, C., & Prados, J. (2019). Electrospun nanofibers: Recent applications in drug delivery and cancer therapy. Nanomaterials, 9(4), 656.
Patrocinador
This research was funded by the Comunidad de Madrid, Spain fellowship “Atracción de Talento Investigador” (2018-T1/IND-10736), Consejería de Salud de la Junta de Andalucía (project PI-0476-2016 and PI-0102-2017) and CICYT, Spain (project CTQ16-76311).Resumen
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to
be specifically applied in several researching fields, including biomedical applications. The principal
researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications,
scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic
hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic
implantable patches or mats to be implemented in numerous biomedical researching fields. In this
context, several biocompatible polymers with excellent biocompatibility and biodegradability
including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol
(PEG), poly (epsilon-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of
NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive
capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with
relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and
non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for
drug delivery applications and cancer treatments. In this review, we focus on the incorporation of
drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal
novelty compared with previously reported publications is that we also focus on recent investigations
concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the
incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with
the capability to respond to external environments, and finally, the synthesis of hybrid polymeric
NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic
hyperthermia applicability.