ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents
Metadatos
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MDPI
Materia
ANGPTL-4 BMI loss Childhood Lipid profile Obesity
Date
2019-06-14Referencia bibliográfica
Barja-Fernández, S., Folgueira, C., Castelao, C., Pena-León, V., González-Saenz, P., Vázquez-Cobela, R., ... & Moreno, L. A. (2019). ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients, 11(6), 1340.
Patrocinador
This research was funded by INSTITUTO DE SALUD CARLOS III cofounded by FEDER, grants number PI18/00998, PI15/01272, PI11/02042, PI16/01301, and PI16/00871, and FUNDACIÓN MUTUA MADRILEÑARésumé
Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy
homeostasis. However, its function in children with obesity remains unknown. We investigated
plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different
lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two
different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal
weight or obesity, we performed a cross-sectional study. In the second cohort, which included only
children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for
weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after
BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with
obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with
BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index
(HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change
in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant
association of ANGPTL-4 with pediatric obesity and plasma lipid profile.