Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework
Metadatos
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Hindawi
Date
2019-02-27Referencia bibliográfica
Torres, J., Faris, I., & Callejas, A. (2019). Histobiomechanical remodeling of the cervix during pregnancy: Proposed framework. Mathematical Problems in Engineering, 2019.
Patrocinador
This research was supported by the Ministry of Education [DPI2017-83859-R, DPI2014-51870-R, DPI2010-17065, and UNGR15-CE-3664], Ministry of Health [DTS15/00093 and PI16/00339, PI-0107-2017, PIN-0030-2017], Junta de Andalucía [P11-CTS-8089], and the European Social Fund (youth employment initiative) projects.Résumé
Pregnancy involves a gradual change in tissue consistency, where, as gestational age increases a drop in stiffness is noticeable. The
extracellularmatrix (ECM) of the cervixwhose behavior is controlled by the collagen structure is reconfigured, due to hormonal and
protein related factors that degraded it. There is an increase in cellular andwater content.Thecollagenmaintains a stable percentage,
although the synthesis-solubility interaction causes a transformation in the network increasing its diameter and waviness, which
destabilizes themechanical integrity. Further understanding of the remodeling of the cervix becomes a key element in the progress
against preterm birth. However, since the woman is in a very delicate state, the available information is scattered.The aim is to
provide a framework where the variation of the histological properties is linked with the individual biomechanical evolution of the
constituents; therefore a multiscale approach to the problem can be made. The results of different authors were reviewed to obtain
values of each component depending on the gestational age, and then they were combined with the mechanical development of
each variable obtained from the outputs of numerical simulations of another author. An additive function is proposed, in which
the mechanical contribution of each constituent is added to a reference value established for a nonpregnant state. Results show how
biochemistry models the mechanical behavior of the tissue through the histology and morphology of the ECM.