Heart Histopathology and Mitochondrial Ultrastructure in Aged Rats Fed for 24 Months on Different Unsaturated Fats (Virgin Olive Oil, Sunflower Oil or Fish Oil) and Affected by Different Longevity
Metadatos
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Navarro Hortal, María Dolores; Ramírez Tortosa, César Luis; Varela López, Alfonso; Romero Márquez, José Manuel; Ochoa Herrera, Julio José; Ramírez Tortosa, María Carmen; Forbes Hernández, Tamara Yuliett; Granados Principal, Sergio; Battino, Maurizio; Quiles Morales, José LuisEditorial
MDPI
Materia
Aging Histology Mitochondrial morphology Inflammation Fibrosis
Fecha
2019-10-07Referencia bibliográfica
Navarro-Hortal, M. D., Ramírez-Tortosa, C. L., Varela-López, A., Romero-Márquez, J. M., Ochoa, J. J., Ramírez-Tortosa, M., ... & Quiles, J. L. (2019). Heart Histopathology and Mitochondrial Ultrastructure in Aged Rats Fed for 24 Months on Different Unsaturated Fats (Virgin Olive Oil, Sunflower Oil or Fish Oil) and Affected by Different Longevity. Nutrients, 11(10), 2390.
Patrocinador
This research was supported by R + D grants from the Spanish Ministry of Education and Science [AGL2008-01057] and the Government of Andalusia [AGR832].Resumen
Diet plays a decisive role in heart physiology, with lipids having especial importance
in pathology prevention and development. This study aimed to investigate how dietary lipids
varying in lipid profile (virgin olive oil, sunflower oil or fish oil) affected the heart of rats during
aging. Heart histopathology, mitochondrial morphometry, and oxidative status were assessed.
Typical histopathological features associated with aging, such as valvular lesions, endomyocardical
hyperplasia, or papillary muscle calcification, were found at a low extent in all the experimental
groups. The most relevant finding was that inflammation registered by fish oil group was lower
compared to the other treatments. At the ultrastructural level, heart mitochondrial area, perimeter,
and aspect ratio were higher in fish oil-fed rats than in those fed on sunflower oil. Concerning
oxidative stress markers, there were differences only in coenzyme Q levels and catalase activity,
lower in sunflower oil-fed animals compared with those fed on fish oil. In summary, dietary intake
for a long period on dietary fats with different fatty acids profile led to differences in some aspects
associated with the aging process at the heart. Fish oil seems to be the fat most protective of heart
during aging.