Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review
Metadatos
Mostrar el registro completo del ítemAutor
Martín Masot, Rafael; Nestares Pleguezuelo, María Teresa; Díaz Castro, Javier; López Aliaga, María Inmaculada; Muñoz Alférez, María José; Moreno Fernández, Jorge; Maldonado Lozano, JoséEditorial
MDPI
Materia
Celiac disease Gluten-free diet Iron deficiency Anemia Micronutrient deficiencies
Fecha
2019-10-23Referencia bibliográfica
Martín-Masot, R., Nestares, M. T., Diaz-Castro, J., López-Aliaga, I., Alférez, M. J. M., Moreno-Fernandez, J., & Maldonado, J. (2019). Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review. Nutrients, 11(11), 2557.
Resumen
Celiac disease (CD) is a multisystemic disorder with di erent clinical expressions, from
malabsorption with diarrhea, anemia, and nutritional compromise to extraintestinal manifestations.
Anemia might be the only clinical expression of the disease, and iron deficiency anemia is
considered one of the most frequent extraintestinal clinical manifestations of CD. Therefore,
CD should be suspected in the presence of anemia without a known etiology. Assessment of
tissue anti-transglutaminase and anti-endomysial antibodies are indicated in these cases and, if
positive, digestive endoscopy and intestinal biopsy should be performed. Anemia in CD has a
multifactorial pathogenesis and, although it is frequently a consequence of iron deficiency, it can be
caused by deficiencies of folate or vitamin B12, or by blood loss or by its association with inflammatory
bowel disease (IBD) or other associated diseases. The association between CD and IBD should be
considered during anemia treatment in patients with IBD, because the similarity of symptoms could
delay the diagnosis. Vitamin B12 deficiency is common in CD and may be responsible for anemia
and peripheral myeloneuropathy. Folate deficiency is a well-known cause of anemia in adults, but
there is little information in children with CD; it is still unknown if anemia is a symptom of the most
typical CD in adult patients either by predisposition due to the fact of age or because biochemical and
clinical manifestations take longer to appear.