Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments
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Springer Nature
Date
2019Referencia bibliográfica
Segarra, A. B., Prieto-Gomez, I., Banegas, I., Martínez-Cañamero, M., de Dios Luna, J., de Gasparo, M., & Ramírez-Sánchez, M. (2019). Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments. Scientific reports, 9(1), 1-15.
Sponsorship
This work was supported by the Ministry of Science and Innovation through project no. SAF 2008 04685 C02 01.Abstract
A lateralized distribution of neuropeptidase activities in the frontal cortex of normotensive and
hypertensive rats has been described depending on the use of some vasoactive drugs and linked to
certain mood disorders. Asymmetrical neuroperipheral connections involving neuropeptidases from the
left or right hemisphere and aminopeptidases from the heart or plasma have been suggested to play
a role in this asymmetry. We hypothesize that such asymmetries could be extended to the connection
between the brain and physiologic parameters and metabolic factors from plasma and urine. To
assess this hypothesis, we analyzed the possible correlation between neuropeptidases from the left
and right frontal cortex with peripheral parameters in normotensive (Wistar Kyoto [WKY]) rats and
hypertensive rats (spontaneously hypertensive rats [SHR]) untreated or treated with vasoactive drugs
such as captopril, propranolol and L-nitro-arginine methyl ester. Neuropeptidase activities from the
frontal cortex were analyzed fluorometrically using arylamide derivatives as substrates. Physiological
parameters and metabolic factors from plasma and urine were determined using routine laboratory
techniques. Vasoactive drug treatments differentially modified the asymmetrical neuroperipheral
pattern by changing the predominance of the correlations between peripheral parameters and central
neuropeptidase activities of the left and right frontal cortex. The response pattern also differed between
SHR and WKY rats. These results support an asymmetric integrative function of the organism and
suggest the possibility of a different neurometabolic response coupled to particular mood disorders,
depending on the selected vasoactive drug.