Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm
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Rodríguez Huertas, Jesús Francisco; Casuso, Rafael A.; Hernansanz Agustín, Pablo; Cogliati, SaraEditorial
Hindawi
Date
2019-06-19Referencia bibliográfica
Huertas, J. R., Casuso, R. A., Agustín, P. H., & Cogliati, S. (2019). Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm. Oxidative Medicine and Cellular Longevity, 2019.
Sponsorship
The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).Abstract
Skeletal muscles require the proper production and distribution of energy to sustain their work. To ensure this requirement is met,
mitochondria form large networks within skeletal muscle cells, and during exercise, they can enhance their functions. In the present
review, we discuss recent findings on exercise-induced mitochondrial adaptations. We emphasize the importance of mitochondrial
biogenesis, morphological changes, and increases in respiratory supercomplex formation as mechanisms triggered by exercise that
may increase the function of skeletal muscles. Finally, we highlight the possible effects of nutraceutical compounds on
mitochondrial performance during exercise and outline the use of exercise as a therapeutic tool in noncommunicable disease
prevention. The resulting picture shows that the modulation of mitochondrial activity by exercise is not only fundamental for
physical performance but also a key point for whole-organism well-being.