Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship
Metadatos
Afficher la notice complèteAuteur
Ruiz Ojeda, Francisco Javier; Anguita-Ruiz, Augusto; Leis, Rosaura; Aguilera García, Concepción MaríaEditorial
Karger
Materia
Vitamin D Adipose tissues Polymorphisms Adipogenesis
Date
2018-07-06Referencia bibliográfica
Ruiz-Ojeda, F. J., Anguita-Ruiz, A., Leis, R., & Aguilera, C. M. (2018). Genetic factors and molecular mechanisms of vitamin D and obesity relationship. Annals of Nutrition and Metabolism, 73, 89-99.
Patrocinador
This work was supported by Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (PI1600871 and IFI17/00048) and Fondo Europeo De Desarrollo Regional (FEDER).Résumé
Vitamin D (vitD) deficiency is associated with a wide range of
chronic diseases and conditions, including obesity, and with
an increasing severity of metabolic dysregulation, such as
insulin resistance, hyperlipidemia, liver disease, and hypertension,
both in children and adults. However, the nature of
the association between low vitD status and obesity remains
unclear. This fact has motivated the scientific community to
conduct genetic association analyses between 25-hydroxyvitamin
D (25[OH]D)-related genes and obesity traits.
In this line, the variation in the vitD receptor (VDR) gene represents
the bulk of the findings. Specifically, polymorphisms
in the VDR gene have been associated with obesity traits in
some but not all, studies. Thus, results regarding this matter
remain inconclusive. Other genes aside from VDR have also
been investigated in relation to obesity-related traits. However,
again, findings have been inconsistent. In general, results
point to the fact that the DBP/GC gene could be an important
protein-linking obesity and vitD status. On the other
hand, several studies have attempted to determine the molecular
mechanism of the relationship between 25(OH)-D
levels and obesity. Some of these studies suggest that vitD,
due to its fat-soluble characteristic, is retained by the adipose tissue and has the capacity to metabolize 25(OH)-D locally,
and this can be altered during obesity. Additionally,
vitD is capable of regulating the gene expression related to
adipogenesis process, inflammation, oxidative stress, and
metabolism in mature adipocytes. Therefore, the aim of the
present review was to evaluate the association between
obesity and vitD deficiency describing the main molecular
mechanism of the relationship and the link with genetic factors