Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers
Identificadores
URI: http://hdl.handle.net/10481/57855Metadata
Show full item recordAuthor
Pozo, Elena; Mesa Aguado, Francisco Luis; Ikram, Mohamed H.; Puertas Prieto, Alberto; Torrecillas-Martínez, Laura; Ortega-Oller, Inmaculada; Magán Fernández, Antonio; Rodríguez-Martínez, María Dolores; Padial Molina, Miguel; Sánchez Fernández, Elena; Galindo Moreno, Pablo Antonio; O'Valle Ravassa, Francisco JavierEditorial
Universidad de Murcia
Materia
Cyclooxygenase 2 Immunohistochemistry Placenta Chronic periodontitis Gingivitis
Date
2016Referencia bibliográfica
Pozo, Elena; et. al. Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. Histol Histopathol (2016) 31: 231-237 [DOI: 10.14670/HH-11-671]
Sponsorship
This investigation was partially supported by Research Group #CTS-138 and #CTS-583 (Junta de Andalucía, Spain).Abstract
The objective of this study was to determine
whether gynecological and periodontal clinical
parameters and the immunohistochemical expression in
placental chorionic villi of the markers cyclooxygenase-
2 (COX-2), interleukin (IL)-1β, vascular endothelial
growth factor receptor 1 (VEGFR1), podoplanin, and
Heat Shock Protein (HSP70) are associated with preterm
birth (PB) and/or low birth weight (LBW) neonates.
Material and methods: An observational casecontrol
study was performed in 130 puerperal women:
mothers of PB/LBW neonates (cases, n=65) and mothers
of full-term normal-weight neonates (controls, n=65).
Data were gathered from all participants on sociodemographic,
gynecological, and periodontal variables
and on placental immunohistochemical COX-2, IL-1β,
VEGFR1, podoplanin, and HSP70 expression.
Results: Among the 42 women with mild/moderate
periodontitis or gingivitis, the studied periodontal
variables were significantly worse and the placental
COX-2 (p=0.043), HSP70 (p=0.001), IL-1β (p=0.001),
VEGFR1 (p=0.032), and podoplanin (p=0.058)
expressions were significantly higher in the cases than in
the controls. In comparison to the mothers without
periodontitis, only COX-2 (p=0.026) and VEGFR1 (p=0.005) expressions were significantly increased in
those with the disease. Increased COX-2 values were
detected in the women with a history of genitourinary
infection (p=0.036), premature rupture of membrane
(p=0.012), or drug treatment (p=0.050).
Conclusions: The etiology of preterm birth and/or
low birth weight is multifactorial and involves
consumption habits, social-health factors, and infectious
episodes. These adverse pregnancy outcomes were
associated with periodontitis and the increased placental
expression of IL-1β, COX-2, VEGFR1, and HSP70.