InterdisciplinaryWeight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
Metadatos
Afficher la notice complèteAuteur
Carneiro Barrera, Almudena; Amaro Gahete, Francisco José; Díaz Román, Amparo; Guillén Riquelme, Alejandro; Jurado Fasoli, Lucas; Sáez Roca, Germán; Martín Carrasco, Carlos; Ruiz Ruiz, Jonatan; Buela Casal, GualbertoEditorial
MDPI
Materia
Obstructive sleep apnoea Apnoea-hypopnoea index Obesity Weight loss Interdisciplinary lifestyle intervention Nutrition Sleep hygiene
Date
2019-09-15Referencia bibliográfica
Carneiro-Barrera, A., Amaro-Gahete, F. J., Díaz-Román, A., Guillén-Riquelme, A., Jurado-Fasoli, L., Sáez-Roca, G., ... & Buela-Casal, G. (2019). Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study. Nutrients, 11(9), 2227.
Patrocinador
This research is supported by the Spanish Ministry of Education and Vocational Training, grant/award numbers FPU16/01093 and FPU14/04172. The study is also partially supported by the Sleep Research Cathedra University of Granada-LoMonaco S.L.; the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES); and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (European Regional Development Funds, ref. SOMM17/6107/UGR).Résumé
Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common
sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and
cardiovascular diseases. Although strongly recommended for this condition, there are no studies on
the e ectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition,
exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled
trial with a two-arm parallel design aimed at determining the e ects of an interdisciplinary tailored
weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged
18–65 with a body mass index of 25 kg/m2 and severe to moderate OSA randomly assigned to
usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle
intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point,
and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other
neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning
and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of
life, and cost-e ectiveness. INTERAPNEA may serve to establish a cost-e ective treatment not only
for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission
of this condition.