Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial
Metadatos
Afficher la notice complèteAuteur
Saliasi, Ina; Llodra Calvo, Juan Carlos; Bravo Pérez, Manuel; Tramini, Paul; Dussart, Claude; Viennot, Stéphane; Carrouel, FlorenceEditorial
MDPI
Materia
Biofilm Anti-inflammatory Carica papaya Interdental bleeding Natural dentifrice Sodium lauryl sulfate free dentifrice Mouthwash Essential oils
Date
2018-11-27Referencia bibliográfica
Saliasi, I. [et al.]. Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial.Int. J. Environ. Res. Public Health 2018, 15, 2660.
Résumé
Clinical research on herbal-based dentifrice +/- mouth rinse products is very limited
compared with the plethora of research on conventional oral care products under normal oral hygiene
conditions. The aim of this study was to determine the anti-inflammatory effects of a novel plant
Carica papaya leaf extract (CPLE) on interdental bleeding in healthy subjects. In this randomized,
single-blind parallel-design study, the eligible subjects were generally healthy non-smokers,
aged 18–26, who exhibited healthy periodontal conditions upon study entry. The participants were
equally randomized into the following four groups: CPLE dentifrice, CPLE dentifrice and mouthwash,
sodium lauryl sulfate (SLS)-free enzyme-containing dentifrice and SLS-free enzyme-containing
dentifrice with essential oil (EO) mouthwash. Subjects were instructed to brush their teeth twice a
day without changing their other brushing habits. Interdental bleeding (BOIP) was measured from
inclusion (T0) until the fourth week (T4) of the study. Clinical efficacy was assessed after one, two,
three and four weeks of home use. The analyses compared BOIP between groups and were then
restricted to participants with ≥70% and then ≥80% bleeding sites at T0. Pairwise comparisons
between groups were performed at T0 and T4, and a logistic regression identified correlates of gingival
bleeding (T4). Among 100 subjects (2273 interdental sites), the median percentage of bleeding sites per
participant at T0 was 65%. The bleeding sites dramatically decreased in all groups between T0 and T4
(relative variations from -54% to -75%, р < 0.01 for all). Gingival bleeding did not significantly differ
between the CPLE dentifrice and the SLS-free dentifrice +/- EO mouthwash groups (from р = 0.05
to р= 0.86), regardless of the baseline risk level. Among the CPLE dentifrice users, fewer bleeding
sites were observed when toothpaste and mouthwash were combined compared to bleeding sites in
those who used toothpaste alone (21% vs. 32%, р = 0.04). CPLE dentifrice/mouthwash provides an
efficacious and natural alternative to SLS-free dentifrice +/-EO-containing mouthwash when used
as an adjunct to mechanical oral care to reduce interdental gingival inflammation.