Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
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Sánchez-Rodríguez, Estefania; Lima-Cabello, Elena; Biel-Glesson, Sara; Fernandez-Navarro, Jose R.; Calleja, Miguel A.; Roca, Maria; Espejo-Calvo, Juan A.; Gil Extremera, Blas; Soria-Florido, Maria; de la Torre, Rafael; Fito, Montserrat; Covas, María Isabel; Alche, Juan de Dios; Martínez De Victoria Muñoz, Emilio; Gil Hernández, Ángel; Mesa, Maria D.Editorial
MDPI
Materia
Olive oil Virgin olive oil Olive oil polyphenols Maslinic acid Oleanolic acid Cardiovascular diseases Endothelial function Phenolic compounds Triterpenes Metabolic syndrome
Date
2018-05-16Referencia bibliográfica
Sanchez-Rodriguez, E. [et al.]. Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial. Nutrients 2018, 10, 626. [http://hdl.handle.net/10481/54954]
Sponsorship
The “NUTRAOLEUM Study” has been supported by the grant ITC-20131031 from the I+D FEDER-INTERCONNECTA (CDTI) and Junta de Andalucía, Spain”.Abstract
The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with
phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers
in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind,
intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils:
(1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO
(OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil
(FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic
syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels
decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake
of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were
found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds,
regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo.
No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed
in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number
NCT02520739).